Associations of maternal insulin sensitivity during pregnancy with childhood central adiposity in the Genetics of Glucose regulation in Gestation and Growth (Gen3G) cohort
Authors' conclusion
Maternal insulin sensitivity during pregnancy may contribute to increased risk for higher offspring central adiposity in middle childhood.
Study context
- Population
- Mother-child pairs, Gen3G cohort; maternal insulin sensitivity at ≈26 weeks of pregnancy, child adiposity at ≈5 years; maternal mean age 28.6 ± 4.3 years, median BMI 24.1 kg/m² in early pregnancy
- Participants
- 422 mother-child pairs
- Outcome
- Association of maternal insulin sensitivity with child adiposity
- Follow-up
- ≈5 years
Main finding
As reported in the abstract
Univariate correlation of lower maternal insulin sensitivity with greater child adiposity (anthropometry, DXA total and trunk % fat), r
−0.122 to −0.159
Matsuda vs DXA trunk % fat, adjusted for covariates incl. maternal BMI (n = 359), β ± SE
−0.034 ± 0.013
p = 0.01
Observational data: associations, not effects.
Original publication
Associations of maternal insulin sensitivity during pregnancy with childhood central adiposity in the Genetics of Glucose regulation in Gestation and Growth (Gen3G) cohort. Pediatr Obes. Published 11 October 2022. doi:10.
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