Are associations of adulthood overweight and obesity with all-cause mortality, cardiovascular disease, and obesity-related cancer modified by comparative body weight at age 10 years in the UK Biobank study?
Main finding · All-cause mortality with adulthood obesity, by childhood body weight (men)Result — go to the resultRatio of HRs 1.28 CI 1.17–1.40Authors' conclusion
Greater risks for all-cause mortality and incident CVD in adults with obesity who perceive themselves to have been a thinner or plumper than average child may be due to confounding and/or recall bias.
Study context
- Population
- Men and women aged 40–69 years (in 2006–2010) in the UK Biobank191,181 men · 242,806 women
- Exposure
- Adulthood weight status by perceived body weight at age 10 years
- Outcome
- Effect modification by childhood body weight of associations of adulthood overweight/obesity with all-cause mortality, incident CVD and incident obesity-related cancer
Methodological detailsUK Biobank, Cox proportional hazards regression, triangulation with polygenic risk scores
- UK Biobank
- Cox proportional hazards regression
- Triangulation with polygenic risk scores
Main finding
As reported in the abstract
All-cause mortality with adulthood obesity, by childhood body weight (men)
Ratio of HRs
1.28
CI 1.17–1.40
By group
About average
1.28
HR · CI 1.21–1.35
Thinner
1.63
HR · CI 1.53–1.75
Observational data: associations, not effects.
Further findings
Genetic analyses (PRS): effect modification for mortality and incident cardiovascular disease (CVD)
- No evidence that association of obesity (adult PRS) with mortality or incident CVD differed by childhood body size (child PRS)
Incident obesity-related cancer
- Evidence for effect modification limited and inconsistent between observational and genetic analyses
Original publication
Are associations of adulthood overweight and obesity with all-cause mortality, cardiovascular disease, and obesity-related cancer modified by comparative body weight at age 10 years in the UK Biobank study? Int J Obes (Lond). Published 23 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →