Comparative Associations of Traditional and New Obesity Framework With Cardio‐Kidney‐Metabolic Syndrome and All‐Cause Mortality: A Prospective Cohort Study
Authors' conclusion
By incorporating central adiposity, the anthropometric criteria improve CKM risk stratification by identifying high-risk individuals overlooked by traditional standards, especially those with adverse body composition despite lower BMI.
Study context
- Population
- UK Biobank participants; mean age 56.8 years, 56% female
- Participants
- 352,740 participants
- Exposure
- Obesity phenotypes by Lancet Commission anthropometric criteria vs traditional body mass index (BMI)-based criteria
- Outcome
- CKM syndrome and all-cause mortality
- Follow-up
- Median 13.2 years
Methodological detailsUK Biobank, Cox models
- UK Biobank
- Cox models
Main finding
As reported in the abstract
CKM syndrome
Each group vs normal weightHazard ratio (95% CI)
Anthropometric excess adiposity & Traditionally-defined non-obesity
1.55(1.52–1.59)
Traditionally-defined obesity & Non-anthropometric excess adiposity
1.61(1.29–2.02)
Both criteriahighest risk
2.61(2.56–2.66)
Anthropometric excess adiposity
2.00(1.96–2.04)
Traditionally-defined obesity
2.45(2.41–2.49)
Observational data: associations, not effects.
Further findings
Cardiovascular-kidney-metabolic (CKM) risk by anthropometric sub-categories
- The three BMI-inclusive definitions yielded similar HRs for CKM risk, higher than those of Traditionally-defined obesity and the non-BMI sub-categories
Original publication
Comparative Associations of Traditional and New Obesity Framework With Cardio‐Kidney‐Metabolic Syndrome and All‐Cause Mortality: A Prospective Cohort Study. Diabetes Obes Metab. Published 21 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →