Intermittent fasting plus early time-restricted eating versus calorie restriction and standard care in adults at risk of type 2 diabetes: a randomized controlled trial
Authors' conclusion
In conclusion, incorporating advice for meal timing with prolonged fasting led to greater improvements in postprandial glucose metabolism in adults at increased risk of developing type 2 diabetes.
Study context
- Population
- Adults at increased risk of developing T2D; 58 ± 10 years, BMI 34.8 ± 4.7 kg m-2
- Participants
- 209 adults
- Comparison
- Intermittent fasting plus early time-restricted eating (iTRE) vs calorie restriction (CR) vs standard care
- Primary endpoint
- Change in glucose AUC in response to a mixed-meal tolerance test, iTRE vs CR
- Follow-up
- Month 6
Methodological detailsopen-label, parallel group, three-arm, randomized 2:2:1, Nutritional support to iTRE and CR for 6 months, with additional 12-month follow-up
- Open-label
- Parallel group
- Three-arm
- Randomized 2:2:1
- Nutritional support to iTRE and CR for 6 months, with additional 12-month follow-up
Primary result
As reported in the abstract
Change in glucose AUC (mixed-meal tolerance test)
iTRE
−10.10
CI −14.08–-6.11 · mg dl-1 min-1
CR
−3.57
CI −7.72–0.57 · mg dl-1 min-1
P = 0.03
Further findings
Glucose tolerance, iTRE vs CR · month 18
- Differences seen at month 6 were lost at month 18
Safety
- Adverse events were transient and generally mild
- Fatigue reports higher with iTRE vs CR and standard care
- Constipation and headache reports higher with iTRE and CR vs standard care
Original publication
Intermittent fasting plus early time-restricted eating versus calorie restriction and standard care in adults at risk of type 2 diabetes: a randomized controlled trial. Nat Med. Published 6 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →