Effect of lifestyle intervention on HbA1c levels in overweight and obese adults with type 2 diabetes across ethnicities: A systematic review and meta-analysis of randomized controlled trials
Authors' conclusion
Lifestyle weight-loss interventions had distinct beneficial effects on HbA1c levels in different ethnic groups with T2DM, especially in Caucasians and Asians.
Study context
- Population
- Overweight or obese adults with T2D across ethnicities (Asians, White/Caucasians, Black/Africans, Hispanics); PubMed/MEDLINE and Web of Science to 31 Dec 2022
- Participants
- 7,580 participants30 studies
- Comparison
- Lifestyle weight-loss intervention vs control
- Outcome
- HbA1c levels (WMD with 95% CI)
Methodological detailsrandom effects model, subgroup analyses by ethnicity, sensitivity analysis
- Random effects model
- Subgroup analyses by ethnicity
- Sensitivity analysis
Pooled result
As reported in the abstract
HbA1c by ethnicity
White/Caucasians: Weighted mean difference (WMD) (95% CI −0.90, −0.28), P < 0.001
−0.59
Asians: WMD (95% CI −0.63, −0.33), P < 0.001
−0.48
Further pooled results
Sensitivity analysis
- Findings remained essentially unchanged
Original publication
Effect of lifestyle intervention on HbA1c levels in overweight and obese adults with type 2 diabetes across ethnicities: A systematic review and meta-analysis of randomized controlled trials. Diabetes Res Clin Pract. Published 6 April 2023. doi:10.
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