Obesity

Six‐ and Twelve‐Month Changes in Body Composition and 24‐h Energy Expenditure After a Very Low‐Calorie Ketogenic Diet

Obesity (Silver Spring)Published Prospective cohort study

Authors' conclusion

These findings provide novel insight into the physiological adaptations following VLCKD

Study context

Population
Women with obesity who completed a 1-month very low-calorie ketogenic diet (VLCKD)
Participants
17 women
Outcome
Body composition (DXA) and 24hEE (whole-room indirect calorimeter)
Follow-up
6 and 12 months

Main finding

As reported in the abstract

6 and 12 months
Body weight change at 6 months, after initial 7% weight loss
−3.9%, p < 0.05
Fat mass change at 6 months
−10%, p < 0.05
Minute-by-minute 24hEE trajectories: significant increase in metabolic rate from 1 to 6 months
p < 0.001

Observational data: associations, not effects.

Original publication

Six‐ and Twelve‐Month Changes in Body Composition and 24‐h Energy Expenditure After a Very Low‐Calorie Ketogenic Diet. Obesity (Silver Spring). Published 15 June 2026. doi:10.1002/oby.70236

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