Effects of Acute Iso- and Hypocaloric Carbohydrate Restriction on Liver Fat and Glucose and Lipid Metabolism
Primary result · Liver fatResult — go to the resultRelative difference (median [IQR]) −16 %Authors' conclusion
Two days of LCHF led to lower liver fat, which was not observed after VLCD. This demonstrates the dynamic regulation of liver fat and the beneficial role of substituting carbohydrates with fat to maintain energy provision. Both LCHF and VLCD had positive effects on fasting parameters for glucose metabolism; however, both diets impaired early β-cell response resulting in deterioration in glucose handling during the meal test.
Study context
- Population
- People with overweight/obesity (BMI 32.5 [31–34] kg/m², median [IQR])crossover
- Participants
- 15 people
- Comparison
- Iso- and hypocaloric carbohydrate restriction vs isocaloric control diet
- Primary endpoint
- Liver fat measured by 1H-magnetic resonance spectroscopy
Methodological detailscrossover, research unit
- Crossover
- Research unit
Primary result
Liver fat
Relative difference (median [IQR])
−16 %
P = 0.020
As reported in the abstract
Further findings
Fasting plasma TG, glucose and insulin
- Lower after both LCHF and VLCD than after CON
Postprandial plasma glucose and insulinogenic index
- Postprandial plasma glucose higher and insulinogenic index lower after both LCHF and VLCD
Original publication
Effects of Acute Iso- and Hypocaloric Carbohydrate Restriction on Liver Fat and Glucose and Lipid Metabolism. J Clin Endocrinol Metab. Published 2 July 2025. doi:10.
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