Effect of time restricted feeding with low carbohydrate, high protein and fat diet without calorie restriction on body weight, blood sugar and lipid profile over 6 months: a retrospective cohort study
Authors' conclusion
TRF with LCHPF diet demonstrated significant improvement in BMI, FBS, HbA1c, triglycerides and HDL. Combining TRF and LCHPF could lead to better individual diabetic management.
Study context
- Population
- People treated with time-restricted feeding plus low carbohydrate, high protein and fat diet without calorie restriction at Clinixero, Kuala Lumpur, February 2021–August 2023
- Exposure
- Time-restricted feeding (TRF) with low carbohydrate and high protein and fat (LCHPF) diet for 3 months vs 6 months
- Outcome
- BMI change from before to after intervention
- Follow-up
- 3 and 6 months
Methodological detailsopen-label, single-centre
- Open-label
- Single-centre
Main finding
As reported in the abstract
- Mean BMI decreased after 3 months, not statistically significant
- p = 0.0572
- BMI decreased significantly after 6 months
- p < 0.0001
Observational data: associations, not effects.
Further findings
Fasting blood sugar (FBS) · 3 and 6 months
- No significant decrease after 3 months
- P = 0.068
- Significantly reduced after 6 months
- P = 0.026
HbA1c · 3 and 6 months
- Significantly decreased after 3 months
- P = 0.019
- Significantly decreased after 6 months
- P < 0.0001
TG · 3 and 6 months
- Significantly reduced after 6 months
- P < 0.001
- Reduction after 3 months
Cholesterol, HDL and LDL · 6 months
- Mean cholesterol, HDL and LDL showed a marked increase
- P < 0.001
Original publication
Effect of time restricted feeding with low carbohydrate, high protein and fat diet without calorie restriction on body weight, blood sugar and lipid profile over 6 months: a retrospective cohort study. Int J Obes (Lond). Published 23 July 2025. doi:10.
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