Network meta-analysis of three different forms of intermittent energy restrictions for overweight or obese adults
Authors' conclusion
ADF may be preferentially prescribed for overweight or obese adults.
Study context
- Population
- Overweight or obese adults; Randomized controlled trials (RCTs) from PubMed, Embase, Cochrane Library and China National Knowledge Infrastructure (CNKI) until August 10, 2022
- Participants
- 1,228 participants16 RCTs
- Comparison
- Alternate-day fasting (ADF) vs 5:2 diet vs time-restricted feeding (TRF) vs CER
- Outcome
- Efficacy of IER forms
Methodological detailsrandom network meta-analysis, modified Cochrane risk of bias tool, Methodological quality ranged from low to moderate
- Random network meta-analysis
- Modified Cochrane risk of bias tool
- Methodological quality ranged from low to moderate
Pooled result
As reported in the abstract
- ADF superior to CER and 5:2 diet in reducing waist circumference
- 5:2 diet superior to CER in reducing BMI
- Fat mass and drop-out comparable across all forms of intermittent energy restriction (IER)
Further pooled results
Sensitivity analyses
- Type of individuals had no influence on pooled results
- ADF significantly reduced weight vs CER
- ADF significant waist circumference reduction vs CER, 5:2 diet and TRF
Original publication
Network meta-analysis of three different forms of intermittent energy restrictions for overweight or obese adults. Int J Obes (Lond). Published 18 November 2023. doi:10. 1038/ s41366-023-01416-z
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