Obesity

Network meta-analysis of three different forms of intermittent energy restrictions for overweight or obese adults

Int J Obes (Lond)Published Network meta-analysis of randomised controlled trials

Authors' conclusion

ADF may be preferentially prescribed for overweight or obese adults.

Study context

Population
Overweight or obese adults; Randomized controlled trials (RCTs) from PubMed, Embase, Cochrane Library and China National Knowledge Infrastructure (CNKI) until August 10, 2022
Participants
1,228 participants16 RCTs
Comparison
Alternate-day fasting (ADF) vs 5:2 diet vs time-restricted feeding (TRF) vs CER
Outcome
Efficacy of IER forms
Methodological detailsrandom network meta-analysis, modified Cochrane risk of bias tool, Methodological quality ranged from low to moderate
  • Random network meta-analysis
  • Modified Cochrane risk of bias tool
  • Methodological quality ranged from low to moderate

Pooled result

As reported in the abstract

  • ADF superior to CER and 5:2 diet in reducing waist circumference
  • 5:2 diet superior to CER in reducing BMI
  • Fat mass and drop-out comparable across all forms of intermittent energy restriction (IER)

Further pooled results

Sensitivity analyses

Type of individuals had no influence on pooled results
ADF significantly reduced weight vs CER
ADF significant waist circumference reduction vs CER, 5:2 diet and TRF

Original publication

Network meta-analysis of three different forms of intermittent energy restrictions for overweight or obese adults. Int J Obes (Lond). Published 18 November 2023. doi:10.1038/s41366-023-01416-z

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