Integrated genetic and epigenetic analyses uncovered GLP1R association with metabolically healthy obesity
Authors' conclusion
Not only the gene polymorphism, but also the DNA methylation of GLP1R was associated with MHO. Epigenetic changes in the methylome may in part explain the relationship between genetic variants and MHO.
Study context
- Population
- Chinese adults; 18 single nucleotide polymorphisms (SNPs) and 31 CpG sites of GLP1R genotyped and methylation-assayed
- Participants
- 300 adults
- Comparison
- Metabolically healthy obesity (MHO) cases vs metabolically healthy normal-weight (MHNW) controls
- MHOn = 180
- MHNWn = 120reference
- Outcome
- Mediation by obesity-related GLP1R methylation sites of the association between GLP1R gene variants and MHO
Methodological detailsgenetic and epigenetic association, causal inference test
- Genetic and epigenetic association
- Causal inference test
Main finding
As reported in the abstract
Association of GLP1R genetic variation and DNA methylation with MHO
- rs4714211 polymorphism of GLP1R significantly associated with MHO
- Methylation sites in the intronic region of GLP1R associated with MHO
- Two of these methylation sites partially mediated the association between genotypes and MHO
- Causal inference test (CIT)
Observational data: associations, not effects.
Original publication
Integrated genetic and epigenetic analyses uncovered GLP1R association with metabolically healthy obesity. Int J Obes (Lond). Published 17 November 2023. doi:10.
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