Gestational diabetes & diabetes in pregnancy
Mendelian randomization analysis of the association between childhood overweight or obesity and gestational diabetes mellitus
Authors' conclusion
Elevated childhood BMI is associated with an increased risk of developing GDM, underscoring the need to address childhood obesity as a preventive strategy. Effective interventions to reduce childhood obesity could be crucial in mitigating this risk.
Study context
- Population
- GWAS data: childhood body mass index (BMI) (39,620 samples, 8,173,382 single-nucleotide polymorphisms (SNPs)); Gestational diabetes mellitus (GDM) (143,441 samples, 12,332 GDM cases, 20,149,608 SNPs)15 SNPs
- Comparison
- Genetically predicted higher childhood BMI and GDM risk
- Outcome
- GDM
Methodological detailstwo-sample GWAS summary data, inverse variance weighting, MR-Egger regression, weighted median
- Two-sample GWAS summary data
- Inverse variance weighting
- MR-Egger regression
- Weighted median
Main finding
As reported in the abstract
GDM per higher childhood BMI (IVW)
OR for GDM with higher childhood BMI (inverse variance weighting (IVW)), 95% CI 1.20-1.87, p < 0.001
1.50
Further findings
Sensitivity and heterogeneity analyses
- Cochran's Q heterogeneity among SNPs
- P = 0.001
- Weighted median β direction consistent with IVW
- No horizontal pleiotropy (MR-Egger intercept, MR-PRESSO, funnel plot)
- Leave-one-out: results largely unchanged
Original publication
Mendelian randomization analysis of the association between childhood overweight or obesity and gestational diabetes mellitus. Diabetes Obes Metab. Published 30 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →