Gestational diabetes & diabetes in pregnancy
Ethnic differences in the effects of lifestyle interventions on adverse pregnancy outcomes among women with gestational diabetes mellitus: A systematic review and meta-analysis
Authors' conclusion
Regardless of ethnic background, this study emphasizes the significant benefits of lifestyle interventions in reducing the risk of macrosomia among women with GDM. However, lifestyle interventions seem to reduce the risk of neonatal hypoglycemia only among Asians, which warrants further studies.
Study context
- Population
- Women with gestational diabetes mellitus (GDM) in randomized controlled trials (RCTs) of lifestyle interventions (PubMed/MEDLINE, Web of Science, Cochrane Library, January 1, 2000 to March 31, 2024); ethnic subgroups Asians, Whites/Caucasians, Hispanics/Latinos, Unknown ethnicity
- Participants
- 4,567 women21 studies
- Comparison
- Lifestyle interventions vs control in women with GDM, by ethnicity
- Outcome
- Adverse pregnancy outcomes, particularly macrosomia and neonatal hypoglycemia, by ethnic group
Methodological detailsrandom effects model, subgroup analysis by ethnicity, sensitivity analyses
- Random effects model
- Subgroup analysis by ethnicity
- Sensitivity analyses
Pooled result
As reported in the abstract
Lifestyle interventions vs ControlRelative risk (95% CI)P value
Macrosomia, all; consistent effects across racial groups
0.54(0.42–0.70)
P < 0.001Neonatal hypoglycemia, Asians
0.56(0.38–0.84)
P = 0.004Further pooled results
- Sensitivity analyses confirmed the robustness of the findings
Original publication
Ethnic differences in the effects of lifestyle interventions on adverse pregnancy outcomes among women with gestational diabetes mellitus: A systematic review and meta-analysis. Diabetes Res Clin Pract. Published 29 September 2024. doi:10.
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