Urinary Bisphenol A and Bis(2-Ethylhexyl) Phthalate Metabolite Concentrations in Children with Obesity: A Case-Control Study
Authors' conclusion
These findings show that a higher exposure to BPA is associated with the risk of obesity in girls. Further studies are needed to unveil the cause-effect relationship.
Study context
- Population
- Obese and normal weight children
- Participants
- 122 participants
- Comparison
- Children with obesity vs normal weight children
- Obesen = 66
- Normal weightn = 56reference
- Outcome
- Urinary excretion of BPA and DEHP metabolites (MEHP, MEHHP, MEOHP)
Methodological detailsUrinary BPA by gas chromatography; DEHP metabolites by high-performance liquid chromatography, Individual determinants of exposure evaluated through "ad hoc" questionnaires
- Urinary BPA by gas chromatography; DEHP metabolites by high-performance liquid chromatography
- Individual determinants of exposure evaluated through "ad hoc" questionnaires
Main finding
As reported in the abstract
Urinary BPA concentration in girls
P < 0.02
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| First step of DEHP metabolic rate in girlsObese girls vs Controls · significantly higher in obese girls | P < 0.05 |
Correlation of DEHP metabolites with leptin in obese girls
- DEHP metabolites correlated significantly with leptin concentrations in obese girls
- P < 0.03
Risk of obesity with BPA above median and habit of eating packaged food
- OR
- 11.09 (95% CI 1.28-95.78)
Original publication
Urinary Bisphenol A and Bis(2-Ethylhexyl) Phthalate Metabolite Concentrations in Children with Obesity: A Case-Control Study. Horm Res Paediatr. Published 16 November 2023. doi:10.
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