Phthalate and phthalate replacement concentrations in relationship to adiposity in a multi-racial cohort of children
Authors' conclusion
We report an inverse association between child urinary DINCH levels, a non-phthalate plasticizer that has replaced DEHP in several applications, and BMI z-score, waist circumference z-score and % body fat in children. Few prior studies of phthalates and their replacements in children have been conducted in diverse populations. Moreover, DINCH has not received a great deal of attention or regulation, but it is a common exposure. In summary, understanding the ubiquitous nature of these chemical exposures and ultimately their sources will contribute to our understanding of their relationship with obesity.
Study context
- Population
- Racial/ethnically diverse children aged 4–8 years
- Participants
- 630 children
- Exposure
- Urinary phthalate and phthalate replacement concentrations vs childhood adiposity/obesity markers
- Outcome
- Association of urinary phthalates (LMW, HMW) and replacements (DINCH, DEHTP) with BMI z-score, waist circumference z-score and % body fat
Main finding
As reported in the abstract
BMI z-score, β
−0.106 (−0.181, −0.031) (95% CI)
Waist circumference z-score, β
−0.119 (−0.189, −0.050) (95% CI)
Percent body fat, β
−0.012 (−0.019, −0.005) (95% CI)
Observational data: associations, not effects.
Further findings
Exposure prevalence
- Children with low molecular weight (LMW) and high molecular weight (HMW) phthalate metabolites
- All
- DINCH above limit of detection
- 88%
Original publication
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