Obesity alters the circadian profiles of energy metabolism and glucose regulation in humans
Authors' conclusion
Obesity is associated with altered circadian energy and glucose metabolism. Understanding and addressing these associations could lead to strategies that improve body weight and metabolic health in people with obesity.
Study context
- Population
- Participants with BMI in the healthy weight or obesity ranges
- Comparison
- Obesity vs healthy weight
- Outcome
- Circadian variation in energy and glucose metabolism
Methodological details5-day in-laboratory protocol, behaviours equally distributed across 24 h, Energy metabolism measured at rest and during a standardized exercise bout; blood sampled before and after each identical meal for glucose and insulin
- 5-day in-laboratory protocol
- Behaviours equally distributed across 24 h
- Energy metabolism measured at rest and during a standardized exercise bout; blood sampled before and after each identical meal for glucose and insulin
Main finding
As reported in the abstract
- Healthy weight: circadian nadir of energy expenditure (rest and exercise) occurred during habitual sleep
- Obesity: nadir of energy expenditure appears to occur during the habitual wake period
- Obesity: relatively greater glucose intolerance during the circadian day
- Obesity: less insulin produced during the circadian night
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Obesity alters the circadian profiles of energy metabolism and glucose regulation in humans. Obesity (Silver Spring). Published 15 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →