Metabolite signature of diabetes remission in individuals with obesity undergoing weight loss interventions
Authors' conclusion
This study confirmed known metabolite associations with obesity/T2D and showed an association of BCAAs with HbA1c change after weight loss, independent of the method or magnitude of weight loss.
Study context
- Population
- Individuals with obesity and T2D undergoing bariatric surgery, lifestyle intervention or usual care; fasting plasma profiled for 139 metabolites before and 2 years after weight loss
- Participants
- 71 / 22 / 66 / 14
- Exposure
- Metabolite changes after weight loss by RYGB, gastric banding, lifestyle intervention or usual care
- RYGBn = 71
- Gastric bandingn = 22
- Lifestyle interventionn = 66
- Usual caren = 14
- Outcome
- Association of metabolite changes with change in HbA1c
- Follow-up
- 2 years
Main finding
As reported in the abstract
- Changes in branched-chain amino acids (BCAAs) (valine, leucine/isoleucine) and branched-chain ketoacids positively associated with change in HbA1c
- false discovery rate q value ≤ 0.001
- Association persisted after adjustment for percentage weight change and RYGB
- p ≤ 0.02
Observational data: associations, not effects.
Further findings
Preintervention BCAAs and adiposity
- BCAAs were associated with preintervention adiposity
Analyses stratified by RYGB or other weight loss method
- Some metabolites showed association with non-RYGB weight loss
Original publication
Metabolite signature of diabetes remission in individuals with obesity undergoing weight loss interventions. Obesity (Silver Spring). Published 14 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →