Renal Cortical Glucose Uptake Is Decreased in Insulin Resistance and Correlates Inversely With Serum Free-fatty Acids
Authors' conclusion
These data confirm differences in renal cortical GU between people with obesity and healthy nonobese controls. Moreover, the negative correlations between renal cortex GU and free fatty acids, ketone bodies, and citrate are suggestive of substrate competition in the renal cortex.
Study context
- Population
- People with obesity and nonobese controls studied with [18F]FDG PET during insulin clamp
- Participants
- 18 vs 18
- Exposure
- People with obesity vs nonobese controls
- Obesityn = 18
- Nonobese controlsn = 18reference
- Outcome
- Renal cortical GU (fractional uptake rate, corrected for residual intratubular [18F]FDG)
- Follow-up
- ∼60 minutes after [18F]FDG injection
Methodological details[18F]FDG PET during insulin clamp, NMR metabolomics
- [18F]FDG PET during insulin clamp
- NMR metabolomics
Main finding
As reported in the abstract
Cortical GU
Nonobese controls
4.7
range 3.4–5.6
Obesity
3.1
range 2.2–4.3
P = 0.004
Observational data: associations, not effects.
Further findings
Correlations of cortical glucose uptake (GU)
- Cortical GU vs M value (insulin sensitivity), r (P = .01)
- 0.42
- Cortical GU vs β-OH-butyrate, r (P = .009)
- −0.58
- Cortical GU vs acetoacetate, r (P = .008)
- −0.48
- Cortical GU vs citrate, r (P = .01)
- −0.44
- Cortical GU vs free fatty acids, r (P < .0001)
- −0.68
- Inverse associations held even when accounting for the M value
Medullary GU
- Medullary GU was not associated with any clinical parameters
Original publication
Renal Cortical Glucose Uptake Is Decreased in Insulin Resistance and Correlates Inversely With Serum Free-fatty Acids. J Clin Endocrinol Metab. Published 13 November 2023. doi:10.
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