Regulation of Cues vs Cognitive Behavioral Therapy for Binge Eating and Weight Loss Among Veterans: A Feasibility and Randomized Clinical Trial
Authors' conclusion
In this randomized clinical trial among veterans with binge eating and obesity, ROC+BWL resulted in greater decreases in binge eating compared with CBT. Although ROC+BWL resulted in greater weight loss compared with CBT during treatment, these differences were not maintained. Thus, ROC+BWL could be an alternate model to treat BED among veterans, but effects on weight need further research.
Study context
- Population
- Veterans with Binge Eating Disorder (BED) or subthreshold BED, body mass index (BMI) 25 to 45, aged 18 to 65 years, university clinic, March 2019 to April 2023; mean age 47.1 years, 59% male, mean BMI 34.8123 provided posttreatment data
- Participants
- 129 veterans
- Comparison
- ROC+behavioral weight loss (BWL) vs cognitive behavioral therapy (CBT)
- ROC+BWLn = 63
- CBTn = 66reference
- Primary endpoint
- Feasibility and change in binge eating (loss of control) and body weight
- Follow-up
- Midtreatment (2.5 months), posttreatment (5 months), 6-month (11 months)
Methodological detailsData provided posttreatment by 123 (95%) and at 6-month follow-up by 115 (89%)
- Data provided posttreatment by 123 (95%) and at 6-month follow-up by 115 (89%)
Primary result
As reported in the abstract
Risk of binge eating · midtreatment, posttreatment, 6-month follow-up
Estimate (95% CrI)
ROC+BWLvs CBTmidtreatment; CrI
difference in probability −0.20(−0.30 to −0.11)
ROC+BWLvs CBT6-month follow-up; CrI
difference in probability −0.21(−0.21 to −0.18)
ROC+BWLvs CBTweight loss, midtreatment; CrI
difference in BMI change −0.68(−1.23 to −0.12)
ROC+BWLvs CBTweight loss, posttreatment; CrI
difference in BMI change −0.71(−1.40 to −0.01)
ROC+BWLvs CBTweight loss, 6-month follow-up; CrI; no longer significant
difference in BMI change −0.22(−0.98 to 0.54)
- Between ROC+BWL and CBT · posttreatment; CrI
- difference in probability −0.23 (95% CrI −0.22 to −0.19)
Further findings
Moderation by clinical binge eating
- Results were more pronounced among veterans with BED
Original publication
Regulation of Cues vs Cognitive Behavioral Therapy for Binge Eating and Weight Loss Among Veterans: A Feasibility and Randomized Clinical Trial. JAMA Netw Open. Published 1 August 2025. doi:10.
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