Low‐calorie, high‐protein diets, regardless of protein source, improve glucose metabolism and cardiometabolic profiles in subjects with prediabetes or type 2 diabetes and overweight or obesity
Authors' conclusion
Low-calorie HP diets improved body composition, glucose metabolism and other cardiometabolic outcomes, regardless of protein source (either animal or plant sources), in outpatients with prediabetes or T2DM.
Study context
- Population
- Adults >18 years with BMI >27.5 kg/m² and prediabetes or T2D
- Participants
- 117 adults
- Comparison
- Low-calorie high-protein diet with mainly plant vs mainly animal protein
Methodological detailsDietary intervention lasted 6 months
- Dietary intervention lasted 6 months
Primary result
As reported in the abstract
Weight loss · 6 months
HPA
−8.05
± 5.12 · kg
HPP
−7.70
± 5.47 · kg
Further findings
Glucose metabolism (fasting glucose, insulin, HOMA-IR, HbA1c)
- Similar beneficial effect with both diets
Lipid profiles, liver enzymes, adipokines, inflammatory biomarkers
- Similarly improved in both groups
Fasting incretins, mainly GLP-1
- Decreased significantly in both groups; correlated with weight loss
Original publication
Low‐calorie, high‐protein diets, regardless of protein source, improve glucose metabolism and cardiometabolic profiles in subjects with prediabetes or type 2 diabetes and overweight or obesity. Diabetes Obes Metab. Published 17 October 2024. doi:10.
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