Association of non‐high‐density lipoprotein cholesterol/high‐density lipoprotein cholesterol ratio with cardiovascular outcomes in patients with type 2 diabetes mellitus: Evidence from the ACCORD cohort
Main finding · MACEResult — go to the resultHazard ratio 1.12 95% CI 1.07–1.16Authors' conclusion
NHHR is a predictor of the risk of developing MACEs and overall mortality in patients with T2DM, with higher NHHR values independently associated with increased future MACE risks after full adjustment for confounders.
Study context
- Population
- Patients with T2D in the ACCORD cohort
- Participants
- 10,188 patients
- Exposure
- Per 1-unit increase in non-HDL-C/HDL-C ratio
- Outcome
- MACE and overall mortality
Methodological detailssecondary analysis of the ACCORD cohort
- Secondary analysis of the ACCORD cohort
Main finding
MACE
Hazard ratio
1.12
95% CI 1.07–1.16
P < 0.0001
Per 1-unit increase in NHHR
HR 1.12 (95% CI 1.07–1.16); P < 0.0001
Per 1-unit increase in NHHR, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Overall mortalityAdjusted | 1.05 (1.01–1.10) | P = 0.0256 | |
| CVD mortalityAdjusted | 1.10 (1.03–1.18) | P = 0.0074 | |
| Non-fatal MIAdjusted | 1.12 (1.05–1.18) | P = 0.0002 | |
| Non-fatal strokeAdjusted | 1.11 (1.02–1.20) | P = 0.0123 | |
| 0.512Hazard ratio (log scale) |
Non-linearity and threshold of NHHR for MACE
- Threshold for MACE (two-stage linear regression)
- 6.28
- Non-linear relationship between NHHR and MACE (non-linearity p < 0.001)
- Adding NHHR to conventional model significantly enhanced predictive accuracy for MACE
Original publication
Association of non‐high‐density lipoprotein cholesterol/high‐density lipoprotein cholesterol ratio with cardiovascular outcomes in patients with type 2 diabetes mellitus: Evidence from the ACCORD cohort. Diabetes Obes Metab. Published 16 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →