Oxidised lipoproteins and the risk of type 2 diabetes mellitus: A 5‐year cohort study on β‐cell dysfunction and prediabetes progression
Authors' conclusion
Ox-HDL-C, ox-LDL-C and ox-Lp(a) are independent, dose-dependent predictors of T2DM development in individuals with prediabetes. Their close association with impaired β-cell function highlights their potential utility in early risk stratification and targeted prevention strategies for T2DM.
Study context
- Population
- Individuals with prediabetes followed for 5 years1,521 with prediabetes
- Participants
- 3,056 individuals
- Exposure
- Higher vs lower baseline oxidised high-density lipoprotein cholesterol (ox-HDL-C), oxidised low-density lipoprotein cholesterol (ox-LDL-C) and ox-Lp levels
- Outcome
- Incident T2DM (progression from prediabetes to T2DM)
- Follow-up
- 5 years
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Progression from prediabetes to T2DM
- Elevated baseline ox-HDL-C, ox-LDL-C and ox-Lp(a) independently associated with increased odds and HRs for progression to T2DM
- Associations dose-dependent and significant across sex-specific subgroups
Observational data: associations, not effects.
Further findings
Correlations with glycaemic, insulin resistance and β-cell indices
- Oxidised lipoproteins correlated positively with FBG, HbA1c and HOMA-IR, and negatively with HOMA-β and HOMA-IS
Original publication
Oxidised lipoproteins and the risk of type 2 diabetes mellitus: A 5‐year cohort study on β‐cell dysfunction and prediabetes progression. Diabetes Obes Metab. Published 9 February 2026. doi:10.
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