High-density lipoprotein cholesterol and kidney disease progression in patients with type 2 diabetes mellitus: the Fukushima Cohort Study
Main finding · Kidney eventsResult — go to the resultAdjusted hazard ratio 2.61 95% CI 1.32–5.14Authors' conclusion
Low HDL-C levels were independently associated with kidney events and all-cause mortality in patients with T2DM. Future studies are warranted to clarify whether interventions targeting HDL-C can improve kidney disease progression in this high-risk population.
Study context
- Population
- Patients with T2D from the Fukushima Cohort Study; median age 66 years, 56% men, median estimated glomerular filtration rate (eGFR) 68.6 mL/min/1.73 m²
- Participants
- 1,033 patients
- Exposure
- Lowest high-density lipoprotein cholesterol (HDL-C) quartile vs reference HDL-C quartile
- Outcome
- Kidney events: ≥50% decrease in eGFR or kidney failure requiring kidney replacement therapy
- Follow-up
- Median 5.3 years
Methodological detailsCox proportional hazards models, multivariable adjusted, lipid parameters in quartiles
- Cox proportional hazards models
- Multivariable adjusted
- Lipid parameters in quartiles
Main finding
Kidney events
Adjusted hazard ratio
2.61
95% CI 1.32–5.14
HDL-C <42 mg/dLvs HDL-C 49-58 mg/dL
aHR 2.61 (95% CI 1.32–5.14)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| All-cause mortality | 2.27 (1.16–4.42) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
All-cause mortality
- U-shaped association between HDL-C and all-cause mortality
Other lipid parameters (triglycerides (TG), LDL-C, non-HDL-C, TG/HDL-C ratio)
- No significant associations with kidney events or mortality
Subgroup and sensitivity analyses
- Consistent
Original publication
High-density lipoprotein cholesterol and kidney disease progression in patients with type 2 diabetes mellitus: the Fukushima Cohort Study. BMJ Open Diabetes Res Care. Published 3 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →