Associations of IDL cholesterol and LDL α-tocopherol with diabetic kidney disease in type 2 diabetes
Authors' conclusion
In patients with T2DM, declining DKD is associated with atherogenic IDL accumulation and increased LDL α-tocopherol content, suggesting altered lipoprotein metabolism that may influence LDL oxidation and cardiovascular risk.
Study context
- Population
- Outpatients with T2D
- Participants
- 188 estimated glomerular filtration rate (eGFR) tertiles
- Exposure
- eGFR tertiles
- Outcome
- Lipoprotein parameters across eGFR tertiles
Main finding
As reported in the abstract
- Intermediate-density lipoprotein cholesterol (IDL-C) levels and LDL-α-tocopherol/LDL-C ratio increased significantly across decreasing eGFR tertiles
- LDL-C levels showed a decreasing trend
- eGFR independently and inversely correlated with IDL-C and LDL-α-tocopherol/LDL-C ratio
Observational data: associations, not effects.
Further findings
Clinical correlates of declining eGFR
- Declining eGFR associated with longer diabetes duration and increased arterial stiffness
Lipid-lowering therapy
- Statin or fibrate therapy associated with lower IDL-C and higher LDL-α-tocopherol/LDL-C ratios
Original publication
Associations of IDL cholesterol and LDL α-tocopherol with diabetic kidney disease in type 2 diabetes. Diabetes Res Clin Pract. Published 28 September 2026. doi:10.
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