Visit-to-visit lipid variability and adverse kidney events in real-world type 2 diabetes patients
Authors' conclusion
An increased risk of adverse kidney events with greater visit-to-visit variability in LDL-C highlights the clinical importance of monitoring both the single-point LDL-C and its stability over time.
Study context
- Population
- Patients with T2D; 54% male, mean age 62.3 years, baseline HbA1c 7.6%, estimated glomerular filtration rate (eGFR) 84.2 mL/min/1.73 m²
- Participants
- 15,444 patients
- Exposure
- Greater vs lower visit-to-visit low-density lipoprotein cholesterol (LDL-C) variability
- Outcome
- Adverse kidney events: sustained eGFR < 15 mL/min/1.73 m², 30% eGFR decline, and composite kidney events
Methodological detailsreal-world
- Real-world
Main finding
As reported in the abstract
Kidney events by LDL-C variability
Average real variability had the best predictive performance; optimal cut-off for sustained eGFR < 15 mL/min/1.73 m²
19.26
Observational data: associations, not effects.
Further findings
Subgroups
- Greater effect of lipid variability on kidney event risk in patients aged < 75 years, with eGFR ≥ 90 mL/min/1.73 m², or with fewer diabetes-related complications
Original publication
Visit-to-visit lipid variability and adverse kidney events in real-world type 2 diabetes patients. Diabetes Res Clin Pract. Published 10 March 2025. doi:10.
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