Coronary Stent Failure in Patients With Diabetes: A Nationwide Observational Study From SWEDEHEART
Authors' conclusion
We observed a significantly higher risk of second-generation DES stent failure in individuals with type 1 diabetes followed by those with type 2 diabetes, compared with individuals without diabetes. This elevated risk was attributed to both in-stent restenosis and stent thrombosis.
Study context
- Population
- All patients in Sweden who received second-generation drug-eluting stents (DES), 2010–2020 (SWEDEHEART); 71% male
- Participants
- 160,523 patients
- Exposure
- T1D or T2D vs no diabetes after second-generation DES
- Type 1 diabetesn = 2,406
- Type 2 diabetesn = 43,377
- Without diabetesn = 114,740reference
- Outcome
- Stent failure: in-stent restenosis or stent thrombosis
- Follow-up
- Mean 4.5 years
Methodological detailsCox regression, sensitivity analyses for missing data and death as competing risk
- Cox regression
- Sensitivity analyses for missing data and death as competing risk
Main finding
As reported in the abstract
Stent failure
Each group vs without diabetesFully adjusted HR (95% CI)
Type 1 diabetes
2.28(1.97–2.65)
Type 2 diabetes
1.35(1.27–1.44)
- Stent failure events, all patients
- 5,510
Observational data: associations, not effects.
Further findings
- Sensitivity analyses confirmed robustness; both in-stent restenosis and stent thrombosis contributed to the increased risk
Original publication
Coronary Stent Failure in Patients With Diabetes: A Nationwide Observational Study From SWEDEHEART. Diabetes Care. Published 27 November 2025. doi:10.
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