Incremental Prognostic Value of a Coronary Heart Disease Polygenic Risk Score in Type 2 Diabetes
Authors' conclusion
The addition of a CHD PRS to clinical assessment improved MACE prediction in T2D individuals without prior cardiovascular disease, particularly in those at low clinical risk.
Study context
- Population
- Individuals with T2D aged 40–79 years without a prior cardiovascular hospitalization
- Participants
- 10,556 individuals
- Exposure
- Coronary heart disease (CHD) polygenic risk score (PRS) added to clinical risk score vs clinical risk score alone
- Outcome
- Time to first MACE incidence; incremental predictive value of CHD PRS to PCE Risk
Main finding
As reported in the abstract
MACE · 10 years
Major adverse cardiovascular events (MACE) events
1,477
CHD PRS association with MACE after adjustment for clinical risk, HR per SD increase
1.69
95% CI 1.60–1.79
PCE Risk <7.5%: top vs lowest quintile of CHD PRS, HR for MACE
10.69
95% CI 5.07–22.55
Observational data: associations, not effects.
Original publication
Incremental Prognostic Value of a Coronary Heart Disease Polygenic Risk Score in Type 2 Diabetes. Diabetes Care. Published 16 October 2024. doi:10.
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