Additive Value of Polygenic Risk Score to Family History for Type 2 Diabetes Prediction: Results From the All of Us Research Database
Authors' conclusion
In predicting T2D, inclusion of a T2D PRS in addition to family history of T2D (first-degree relatives) added statistical value. Further study is needed to determine whether consideration of both family history and a PRS would be useful for clinical T2D prediction.
Study context
- Population
- All of Us research participants
- Participants
- 109,958 participants
- Exposure
- Polygenic risk score (PRS) plus family history vs family history alone vs PRS alone for T2D prediction
- Outcome
- T2D prediction (AUC)
Methodological detailsAll of Us research database, logistic regression adjusted for age, sex and BMI
- All of Us research database
- Logistic regression adjusted for age, sex and BMI
Main finding
As reported in the abstract
Predictive performance for T2D (AUC)
| Group | Value | AUC |
|---|---|---|
| PRS + family history | 0.794 | 0.794 |
| Family history | 0.763 | 0.763 |
| PRS | 0.785 | 0.785 |
Value
PRS + family history0.794
Family history0.763
PRS0.785
AUC
PRS + family history0.794
Family history0.763
PRS0.785
Observational data: associations, not effects.
Further findings
Odds of T2D, separate models
| OR (95% CI) | ||
|---|---|---|
| 1 SD PRSAdjusted for age, sex and BMI | 1.75 (1.71–1.79) | |
| Positive T2D family historyAdjusted for age, sex and BMI | 2.32 (2.20–2.43) | |
| 0.512Odds ratio (log scale) |
Odds of T2D, joint model
| OR (95% CI) | ||
|---|---|---|
| 1 SD PRS | 1.69 (1.65–1.72) | |
| Family history | 2.06 (1.98–2.15) | |
| 0.512Odds ratio (log scale) |
- Both significantly associated with T2D; Odds ratios (ORs) slightly attenuated
Original publication
Additive Value of Polygenic Risk Score to Family History for Type 2 Diabetes Prediction: Results From the All of Us Research Database. Diabetes Care. Published 22 January 2025. doi:10.
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