Impact of diabetes remission or progression on the incidence of cardiovascular disease in Japan: historical cohort study using a nationwide claims database
Main finding · CVDResult — go to the resultHazard ratio 0.71 95% CI 0.57–0.89Authors' conclusion
In a real-world setting without intensive intervention, diabetes remission decreased the risk of CVD by approximately 30% regardless of changes in BMI, suggesting that diabetes remission can prevent CVD without weight loss in routine care and emphasizing the importance of achieving remission.
Study context
- Population
- Individuals aged 20–72 years in Japan with multiple checkups 2008–2020 and ≥3 years of follow-up; groups by HbA1c change and diabetes medication use during 1-year baseline
- Participants
- 299,967 individuals
- Exposure
- Diabetes mellitus (DM) remission or progression groups by HbA1c change and diabetes medication use
- Outcome
- Incidence of cardiovascular disease (CVD)
- Follow-up
- Median 5.0 years
Methodological detailshistorical cohort, nationwide claims database, multivariable Cox regression
- Historical cohort
- Nationwide claims database
- Multivariable Cox regression
Main finding
CVD
Hazard ratio
0.71
95% CI 0.57–0.89
By group
DM+/no remission
7.96 per 1000 person-years
DM+/remission
4.76 per 1000 person-years
DM-/no progression
1.99 per 1000 person-years
DM-/progression
5.47 per 1000 person-years
DM+/remissionvs DM+/no remission
HR 0.71 (95% CI 0.57–0.89)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CVD, subgroup change in BMI ≤ 0%DM+/remissionvs DM+/no remission | 0.75 (0.56–0.99) | |
| CVD, subgroup change in BMI > 0%DM+/remissionvs DM+/no remission | 0.66 (0.45–0.96) | |
| 0.512Hazard ratio (log scale) |
Original publication
Impact of diabetes remission or progression on the incidence of cardiovascular disease in Japan: historical cohort study using a nationwide claims database. Cardiovasc Diabetol. Published 22 January 2025. doi:10.
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