Triglyceride-glucose-body mass index and the incidence of cardiovascular diseases: a meta-analysis of cohort studies
Pooled result · CVDResult — go to the resultHazard ratio 1.62 95% CI 1.35–1.95Authors' conclusion
Higher TyG-BMI may be independently associated with an increased risk of CVD in individuals without CVD at baseline. Numerous cohort studies are needed to further validate and elucidate the pathologic role between Tyg-BMI and CVD and to determine whether it can be incorporated into CVD risk prediction tools to enhance predictive accuracy.
Study context
- Population
- Individuals without CVD at baseline
- Participants
- 871,728 individuals10 cohort studies
- Comparison
- Highest vs lowest TyG-BMI index category
- Outcome
- Incidence of CVD
Methodological detailsrandom-effects model, dose-response meta-regression
- Random-effects model
- Dose-response meta-regression
Pooled result
CVD
Hazard ratio
1.62
95% CI 1.35–1.95
Highest TyG-BMIvs Lowest TyG-BMI
HR 1.62 (95% CI 1.35–1.95)
As reported in the abstract
Further pooled results
| Outcome | HR (95% CI) | |
|---|---|---|
| CADI2 = 94% | 1.69 (1.23–2.31) | |
| StrokeI2 = 94% | 1.57 (1.11–2.23) | |
| 0.512Hazard ratio (log scale) |
Dose-response: TyG-BMI index and risk
- Linear association with CVD risk
- Pnonlinear = 0.223
- Linear association with coronary artery disease (CAD) risk
- Pnonlinear = 0.693
- Linear association with stroke risk
- Pnonlinear = 0.122
Subgroups: gender, follow-up length, sample size, mean age
- No significant effects observed
- P > 0.05
Original publication
Triglyceride-glucose-body mass index and the incidence of cardiovascular diseases: a meta-analysis of cohort studies. Cardiovasc Diabetol. Published 22 January 2025. doi:10.
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