Triglyceride-glucose index and heart failure: a systematic review and meta-analysis
Authors' conclusion
Our findings support the TyG index as a valuable marker to assess the risk of HF incidence in different populations and as a prognostic marker in patients with HF. Further studies should be conducted to confirm these associations and investigate the clinical utility of the TyG index.
Study context
- Population
- Studies investigating the TyG index in patients with heart failure (HF) or its association with the incidence of HF (PubMed, Embase, Scopus, Web of Science)
- Participants
- 772,809 participants30 studies
- Comparison
- Highest vs lowest TyG index group; TyG per 1-unit increase
- Outcome
- Risk of HF incidence (adjusted HR)
Methodological detailsrandom-effect meta-analysis, adjusted HRs pooled
- Random-effect meta-analysis
- Adjusted HRs pooled
Pooled result
As reported in the abstract
Risk of HF
Hazard ratio (95% CI)P value
Highest TyGvs Lowest TyG7 studies
1.21(1.14–1.29)
P < 0.01TyG per 1-unit increase
1.17(1.08–1.26)
Further pooled results
Incidence of HF in T2D or coronary artery disease
- Higher TyG associated with higher incidence of HF in patients with T2D or coronary artery disease
Adverse events (readmission and mortality) in patients with HF
- Incidence of adverse events (readmission and mortality) in HF associated with TyG
Original publication
Triglyceride-glucose index and heart failure: a systematic review and meta-analysis. Cardiovasc Diabetol. Published 7 September 2023. doi:10.
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