Mitochondrial DNA Copy Number and Risk of Diabetes Mellitus and Metabolic Syndrome
Authors' conclusion
Decreased mtDNA-CN was associated with increased risk of diabetes mellitus and MetS when limited to prospective studies. More longitudinal studies are warranted.
Study context
- Population
- Observational studies of mtDNA copy number (mtDNA-CN) and DM and metabolic syndrome (MetS); PubMed, EMBASE, Web of Science searched to December 15, 20226 articles (12 studies)
- Comparison
- Lowest vs highest mtDNA-CN
- Outcome
- Risk of DM and MetS
Methodological detailsrandom-effect models, 19 articles in systematic review
- Random-effect models
- 19 articles in systematic review
Pooled result
As reported in the abstract
Lowest mtDNA-CN vs Highest mtDNA-CNEstimate (95% CI)
I2 = 79.4%; n = 8
summary RR, DM 1.06(1.01–1.12)
I2 = 70.6%; n = 4
summary RR, MetS 1.03(0.99–1.07)
Further pooled results
| Outcome | Estimate | |
|---|---|---|
| DM by study designLowest mtDNA-CNvs Highest mtDNA-CNI2 = 22.6%; n = 4 | RR, prospective 1.11 (CI 1.02–1.21) | |
| DM by study designLowest mtDNA-CNvs Highest mtDNA-CNI2 = 81.8%; n = 2 | RR, case-control 1.27 (CI 0.66–2.43) | |
| DM by study designLowest mtDNA-CNvs Highest mtDNA-CNI2 = 74.7%; n = 2 | RR, cross-sectional 1.01 (CI 0.99–1.03) | |
| MetS by study designLowest mtDNA-CNvs Highest mtDNA-CNI2 = 0; n = 2 | RR, prospective 2.87 (CI 1.51–5.48) | |
| MetS by study designLowest mtDNA-CNvs Highest mtDNA-CNI2 = 0; n = 2 | RR, cross-sectional 1.02 (CI 1.01–1.04) | |
| 0.20.5125Ratio (log scale) |
Original publication
Mitochondrial DNA Copy Number and Risk of Diabetes Mellitus and Metabolic Syndrome. J Clin Endocrinol Metab. Published 11 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →