Diagnostic and prognostic value of triglyceride glucose index: a comprehensive evaluation of meta-analysis
Authors' conclusion
The TyG index is a promising biomarker for screening and predicting various medical conditions, particularly those related to insulin resistance and metabolic disorders. However, the heterogeneity and methodological quality of the included studies suggest the need for further high-quality research to confirm these findings and refine the clinical utility of the TyG index.
Study context
- Population
- Meta-analyses on the Triglyceride and Glucose (TyG) index in various clinical settings; PubMed, Scopus and Web of Science searched up to April 14, 2024studies included
- Participants
- 32 studies
- Comparison
- High vs low TyG index
- Outcome
- Associations of TyG index with health outcomes
Methodological detailsAMSTAR2 quality assessment, Statistical analyses with Comprehensive Meta-Analysis (CMA) software
- AMSTAR2 quality assessment
- Statistical analyses with Comprehensive Meta-Analysis (CMA) software
Pooled result
As reported in the abstract
- Contrast-induced nephropathy, high TyG: OR
- 2.24 (95% CI 1.82-2.77)
- Chronic kidney disease (CKD), high TyG: RR
- 1.46 (95% CI 1.32-1.63)
- T2D, high TyG: RR
- 3.53 (95% CI 2.74-4.54)
- Gestational diabetes mellitus (GDM), high TyG: OR
- 2.41 (95% CI 1.48-3.91)
- Diabetic retinopathy (DR), high TyG: OR
- 2.34 (95% CI 1.31-4.19)
- TyG higher in obstructive sleep apnea vs without: SMD
- 0.86 (95% CI 0.57-1.15)
- TyG higher in metabolic syndrome vs without: MD
- 0.83 (95% CI 0.74-0.93)
- Non-alcoholic fatty liver disease (NAFLD): OR
- 2.36 (95% CI 1.88-2.97)
- Dementia, higher TyG: OR
- 1.14 (95% CI 1.12-1.16)
- Cognitive impairment, higher TyG: OR
- 2.31 (95% CI 1.38-3.86)
- Ischemic stroke, higher TyG: OR
- 1.37 (95% CI 1.22-1.54)
- Heart failure (HF): HR
- 1.21 (95% CI 1.12-1.30)
- Atrial fibrillation (AF): SMD
- 1.22 (95% CI 0.57-1.87)
- Hypertension: RR
- 1.52 (95% CI 1.25-1.85)
Original publication
Diagnostic and prognostic value of triglyceride glucose index: a comprehensive evaluation of meta-analysis. Cardiovasc Diabetol. Published 23 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →