The effects of canagliflozin in type 2 diabetes in subgroups defined by population‐specific body mass index: Insights from the CANVAS Program and CREDENCE trial
Authors' conclusion
The cardiovascular and renal benefits of canagliflozin and its safety profile were consistent across population-specific BMI subgroups for adults in the CANVAS Program and CREDENCE trial.
Study context
- Population
- Adults with T2D in the CANVAS Program and CREDENCE trial; 9378 (65%) with obesity
- Participants
- 14,520 adults
- Comparison
- Canagliflozin vs comparator across population-specific body mass index (BMI) categories
- Primary endpoint
- MACE (nonfatal MI, nonfatal stroke or cardiovascular death); composite renal outcome; changes in SBP, body weight, albuminuria and eGFR slope
Methodological detailssubgroups by population-specific BMI
- Subgroups by population-specific BMI
Primary result
As reported in the abstract
Treatment effect across BMI subgroups
- Major adverse cardiovascular events (MACE): no heterogeneity across BMI subgroups
- Pheterogeneity = 0.76
- Composite renal outcome: no heterogeneity across subgroups
- Pheterogeneity = 0.72
- Body weight: effect differed across BMI subgroups
- Pheterogeneity <0.01
- Systolic blood pressure (SBP): effect differed across BMI subgroups
- 0.04
- Albuminuria: effect consistent across subgroups
- Pheterogeneity = 0.60
- Chronic estimated glomerular filtration rate (eGFR) slope: consistent across subgroups
- Pheterogeneity >0.95
Further findings
MACE, overall
| HR (95% CI) | ||
|---|---|---|
| Canagliflozin | 0.83 (0.75–0.93) | |
| 0.512Hazard ratio (log scale) |
Composite renal outcome, overall
| HR (95% CI) | ||
|---|---|---|
| Canagliflozin | 0.75 (0.66–0.84) | |
| 0.512Hazard ratio (log scale) |
Original publication
The effects of canagliflozin in type 2 diabetes in subgroups defined by population‐specific body mass index: Insights from the CANVAS Program and CREDENCE trial. Diabetes Obes Metab. Published 6 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →