Achievement of HbA1c and weight targets in adults with type 2 diabetes on once weekly injectable glucagon‐like peptide‐1 receptor agonist therapy in UK primary care: A retrospective, real‐world study
Authors' conclusion
Two thirds of T2D patients receiving QW injectable GLP-1 RA for 6 months did not attain target HbA1c < 7%, and less than half and one-quarter of patients achieved ≥5% and ≥10% weight loss, respectively. Results suggest an unmet need for better clinical management of T2D in UK primary care.
Study context
- Population
- Adults with T2D newly initiating a QW injectable GLP-1 RA, Jan 2020–Nov 2021, UK primary care; mean ± SD age 58.8 ± 11.4 years, baseline HbA1c 9.3% ± 1.7%, BMI 36.6 ± 7.2 kg/m²
- Participants
- 10,816 adults
- Outcome
- Dual: proportion with HbA1c < 7% (<53 mmol/mol); weight loss categories (0% to 15+%)
- Follow-up
- 6 months of continuous GLP-1 RA therapy
Methodological detailsnon-interventional, real-world, Clinical Practice Research Datalink Aurum primary care database
- Non-interventional
- Real-world
- Clinical Practice Research Datalink Aurum primary care database
Main finding
As reported in the abstract
6 months
- Achieved HbA1c < 7% (of 5236 with data)
- 32.8%
- Did not lose weight (of 3963 with weight data)
- 22.0%
- Weight reduction >0%-<5%
- 34.0%
- Weight reduction ≥5%-<10%
- 27.0%
- Weight reduction ≥10%-<15%
- 11.4%
- Weight reduction ≥15%
- 5.6%
Observational data: associations, not effects.
Further findings
HbA1c < 7% by time since T2D diagnosis · 6 months
- <5 years
- 34.1%
- ≥5-<10 years
- 28.0%
- ≥10-<15 years
- 18.7%
- ≥15 years
- 19.3%
Weight loss by diabetes duration · 6 months
- No major differences in weight loss by diabetes duration
Original publication
Achievement of HbA1c and weight targets in adults with type 2 diabetes on once weekly injectable glucagon‐like peptide‐1 receptor agonist therapy in UK primary care: A retrospective, real‐world study. Diabetes Obes Metab. Published 22 January 2025. doi:10.
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