Evaluation of a program designed to prevent diabetic nephropathy aggravation: A retrospective cohort study using health checkups and claims data in Japanese municipalities
Authors' conclusion
Early in the program, renal function did not improve in the intervened patients or program-implementing municipalities. Diverse eGFR changes across municipalities highlighted diverse intervention outcomes, emphasizing the need of program refinement.
Study context
- Population
- Patients with T2D in the Kokuho Database from program-implementing and non-implementing municipalities, Japan, FYs 2015–202189,611/89,685 eligible (FY 2016/2018)
- Exposure
- Diabetic Nephropathy Aggravation Prevention Program intervention vs no intervention
- Outcome
- Average treatment effect on the treated on ΔeGFR
- Follow-up
- 3 years
Methodological detailsinverse probability of treatment weighting, health checkups and claims data, Japanese municipalities
- Inverse probability of treatment weighting
- Health checkups and claims data
- Japanese municipalities
Main finding
As reported in the abstract
ΔeGFR, Comparison A (intervened vs non-intervened in implementing municipalities)
Estimated effect
−0.4 mL/min/1.73 m²
95 % CI −1.0 to 0.2
FY 2016
Estimated effect
−0.4 mL/min/1.73 m²
95 % CI −0.9 to 0.1
FY 2018
- Intervened patients (FY 2016/2018), among 68,125/68,170 in implementing municipalities
- 1,470/1,819
Observational data: associations, not effects.
Further findings
ΔeGFR, Comparisons B and C
- Comparisons B and C demonstrated similar tendency
- Distribution of %change in eGFR varied between municipalities
Original publication
Evaluation of a program designed to prevent diabetic nephropathy aggravation: A retrospective cohort study using health checkups and claims data in Japanese municipalities. Diabetes Res Clin Pract. Published 30 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →