Data-driven Cluster Analysis Reveals Increased Risk for Severe Insulin-deficient Diabetes in Black/African Americans
Main finding · Diabetes cluster distributionResult — go to the resultOdds ratio 1.83 95% CI 1.36–2.45Authors' conclusion
Racial background greatly influences diabetes cluster distribution and Black/African Americans are more frequently and more severely affected by severe insulin-deficient diabetes. This may further help explain the disparity in outcomes and have implications for treatment choice.
Study context
- Population
- Adults with diabetes (ICD codes) diagnosed 2010–2019 at the Kirklin Clinic, University of Alabama at Birmingham, with data for 6 clustering parameters (GADA, HbA1c, BMI, diagnosis age, HOMA2-B, HOMA2-IR); ∼42% Black/African American
- Participants
- 89,875 adults
- Exposure
- Black/African Americans vs Whites
- Outcome
- Diabetes subtypes and their associated characteristics based on clustering analysis
Methodological detailshierarchical cluster analysis, electronic health records, single-centre ambulatory referral center, Outcome and hypothesis formulated prior to data collection
- Hierarchical cluster analysis
- Electronic health records
- Single-centre ambulatory referral center
- Outcome and hypothesis formulated prior to data collection
Main finding
Diabetes cluster distribution
Odds ratio
1.83
95% CI 1.36–2.45
P < 0.001
Black/African Americansvs Whites
OR 1.83 (95% CI 1.36–2.45); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Risk for complications | 1.42 (1.06–1.90) | P = 0.020 | |
| 0.512Odds ratio (log scale) |
| Outcome | P value |
|---|---|
| β-cell function (HOMA2-B, C-peptide)More severe impairment in Black/African Americans | P < 0.001 |
β-cell function (HOMA2-B, C-peptide)
- Black/African Americans not more obese or insulin resistant
Original publication
Data-driven Cluster Analysis Reveals Increased Risk for Severe Insulin-deficient Diabetes in Black/African Americans. J Clin Endocrinol Metab. Published 30 July 2024. doi:10.
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