Impact of age on estimated glomerular filtration rate (eGFR) dynamics following sodium-glucose cotransporter 2 inhibitor therapy: A real-world study
Authors' conclusion
Older patients showed a more pronounced initial eGFR decline after starting SGLT2i, but it stabilized for one year without further deterioration, similar to younger patients.
Study context
- Population
- Patients newly prescribed SGLT2i; 34.5% aged 60–69, 21.1% aged 70–79, 11.5% aged ≥80 years
- Participants
- 2,070 patients
- Exposure
- Initial eGFR dip after SGLT2i initiation across age groups
- Outcome
- Significant initial dip: >10% reduction in eGFR at 3 months
- Follow-up
- 3 months
Methodological detailsreal-world data
- Real-world data
Main finding
As reported in the abstract
Significant initial eGFR dip (>10%)
Patients with significant dip, overall
21.4 %
Incidence of initial dip increases with age; highest in aged 80+
38.7 %
Observational data: associations, not effects.
Further findings
1-year eGFR change after initial decline · 12 months
- Subsequent eGFR stable over one year in all age groups
Factors linked to initial dip
- Age, lower hemoglobin, higher uric acid and RAS blocker use linked to initial dip
Original publication
Impact of age on eGFR dynamics following sodium-glucose cotransporter 2 inhibitor therapy: A real-world study. Diabetes Res Clin Pract. Published 29 July 2024. doi:10.
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