Type 2 & other diabetes

Capillary Glycated Hemoglobin A1c Percentiles and the Risk Factors Associated with Abnormal HbA1c among Chinese Children Aged 3–12 Years

Pediatr DiabetesPublished Cross-sectional study

Authors' conclusion

The present study established capillary HbA1c percentiles based on a large sample of Chinese children among aged 3-12 years. Daily sleep duration and frequency of outdoor activity, BMI, and TC were found to be associated with high HbA1c. Actions of successful public strategies that focus on promoting a healthy lifestyle, including regular physical exercise to reduce weight among children, are needed. Key Points. We used POC testing for capillary HbA1c with a finger-stick sample which may offer an opportunity to enhance screening and early diagnosis for childhood and adolescent diabetes, which was suggested as an essential premise to determine the subject's glycemic status by the American Diabetes Association (ADA). Capillary HbA1c levels fluctuate during childhood, while there has been no population-based study on HbA1c reference values in Chinese youths.

Study context

Population
Chinese children aged 3–12 years, Shanghai Children's Health and Nutrition Community-based Epidemiologic Survey (CHANCE)
Participants
4,615 children
Outcome
Capillary HbA1c percentiles; abnormal HbA1c defined as ≥95th percentile of the nomograms
Methodological detailscommunity-based, point-of-care testing
  • Community-based
  • Point-of-care testing

Main finding

As reported in the abstract

Capillary HbA1c

Mean HbA1c

5.30%

SD = 0.50%

Age-specific 95th percentile thresholds of HbA1c (%)

5.9 to 6.2

Observational data: associations, not effects.

Further findings

Factors associated with high HbA1c, all children

Body mass index (BMI), total cholesterol, outdoor activity frequency and daily sleep duration positively associated with high HbA1c

Factors associated with high HbA1c, preschool-aged children

Total cholesterol and sleep duration ≥10 hr/day associated with increased risk of higher HbA1c
both P < 0.05

Factors associated with HbA1c, school-aged children

Positive associations for total cholesterol, living with grandparents, outdoor activity frequency and sleep duration
all P < 0.05

Original publication

Capillary Glycated Hemoglobin A1c Percentiles and the Risk Factors Associated with Abnormal HbA1c among Chinese Children Aged 3–12 Years. Pediatr Diabetes. Published 29 July 2024. doi:10.1155/2024/8333590

Composed by AI from the published abstract and checked against it. How Briefs are made →

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