Capillary Glycated Hemoglobin A1c Percentiles and the Risk Factors Associated with Abnormal HbA1c among Chinese Children Aged 3–12 Years
Authors' conclusion
The present study established capillary HbA1c percentiles based on a large sample of Chinese children among aged 3-12 years. Daily sleep duration and frequency of outdoor activity, BMI, and TC were found to be associated with high HbA1c. Actions of successful public strategies that focus on promoting a healthy lifestyle, including regular physical exercise to reduce weight among children, are needed. Key Points. We used POC testing for capillary HbA1c with a finger-stick sample which may offer an opportunity to enhance screening and early diagnosis for childhood and adolescent diabetes, which was suggested as an essential premise to determine the subject's glycemic status by the American Diabetes Association (ADA). Capillary HbA1c levels fluctuate during childhood, while there has been no population-based study on HbA1c reference values in Chinese youths.
Study context
- Population
- Chinese children aged 3–12 years, Shanghai Children's Health and Nutrition Community-based Epidemiologic Survey (CHANCE)
- Participants
- 4,615 children
- Outcome
- Capillary HbA1c percentiles; abnormal HbA1c defined as ≥95th percentile of the nomograms
Methodological detailscommunity-based, point-of-care testing
- Community-based
- Point-of-care testing
Main finding
As reported in the abstract
Mean HbA1c
5.30%
SD = 0.50%
Age-specific 95th percentile thresholds of HbA1c (%)
5.9 to 6.2
Observational data: associations, not effects.
Further findings
Factors associated with high HbA1c, all children
- Body mass index (BMI), total cholesterol, outdoor activity frequency and daily sleep duration positively associated with high HbA1c
Factors associated with high HbA1c, preschool-aged children
- Total cholesterol and sleep duration ≥10 hr/day associated with increased risk of higher HbA1c
- both P < 0.05
Factors associated with HbA1c, school-aged children
- Positive associations for total cholesterol, living with grandparents, outdoor activity frequency and sleep duration
- all P < 0.05
Original publication
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