Glycemic Control, Cognitive Aging, and Impairment Among Diverse Hispanic/Latino Individuals: Study of Latinos– Investigation of Neurocognitive Aging (Hispanic Community Health Study/Study of Latinos)
Authors' conclusion
Elevated HbA1c levels were associated with 7-year executive cognitive decline and increased MCI risk among diverse middle-aged and older Hispanic/Latino individuals. Our findings indicate that poor glycemic control in midlife may pose significant risks for cognitive decline and MCI later in life among Hispanic/Latino individuals of diverse heritages.
Study context
- Population
- Diverse Hispanic/Latino individuals aged ≥50 years (Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA), 2016–2018); exposure measured at HCHS/SOL visit 1 (2008–2011); Bronx, Chicago, Miami, San Diego
- Participants
- 6,377 individuals
- Exposure
- Higher vs lower hemoglobin A1C (HbA1c) at visit 1
- Outcome
- Cognitive function, 7-year cognitive decline, and MCI
- Follow-up
- 7 years
Methodological detailsancillary study of HCHS/SOL, multisite, probability sampled
- Ancillary study of HCHS/SOL
- Multisite
- Probability sampled
Main finding
As reported in the abstract
Higher HbA1c (covariate-adjusted)
Accelerated 7-year global cognitive decline per higher HbA1c, b (z score units), 95% CI −0.070; −0.021
−0.045
Higher prevalence of mild cognitive impairment (MCI), OR
1.20
95% CI 1.11; 1.29
Observational data: associations, not effects.
Original publication
Glycemic Control, Cognitive Aging, and Impairment Among Diverse Hispanic/Latino Individuals: Study of Latinos– Investigation of Neurocognitive Aging (Hispanic Community Health Study/Study of Latinos). Diabetes Care. Published 29 April 2024. doi:10.
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