Mortality patterns in Dutch diabetes outpatients
Authors' conclusion
Mortality among Dutch outpatients with diabetes is high. Smoking and renal failure were associated with mortality in both types. Further focus on early detection and treatment of mortality-associated factors may improve clinical outcomes.
Study context
- Population
- People with DM visiting Dutch diabetes outpatient clinics in 2016–2020, nationwide Dutch Paediatric and Adult Registry of Diabetes (DPARD)
- Participants
- 12,992 people
- Exposure
- Adult T1D vs T2D
- Outcome
- All-cause and cardiovascular mortality rates, causes and predictors
- Follow-up
- Median 3.1 years
Methodological detailsnationwide registry (DPARD) linked to Statistics Netherlands, Cox proportional hazard regression, DPARD data linked to Statistics Netherlands (CBS) for mortality, ethnicity and education
- Nationwide registry (DPARD) linked to Statistics Netherlands
- Cox proportional hazard regression
- DPARD data linked to Statistics Netherlands (CBS) for mortality, ethnicity and education
Main finding
As reported in the abstract
Mortality rate per 10 000 person-years
Observational data: associations, not effects.
Further findings
Causes of death
- Major cause of non-cardiovascular death was malignancy
Calendar pattern
- Mortality rates peaked in pandemic years of influenza (2018) and COVID (2020)
Predictors of all-cause mortality
- Age, smoking and eGFR <60 ml/min associated with all-cause mortality
- In T2D additionally: male sex, BMI <20 kg/m², diabetes duration <1 year and hypertension
Original publication
Mortality patterns in Dutch diabetes outpatients. Diabetes Obes Metab. Published 29 July 2024. doi:10.
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