Impact of type 2 diabetes and its duration on incidence rates of dementia death and medication prescription in the Australian population during 2003–2016
Authors' conclusion
A higher incidence of AD death in the setting of 10+ years of diabetes duration coupled with a lower incidence of AD treatment suggests an under-recognition of this dementia phenotype among people with type 2 diabetes.
Study context
- Population
- Australians with T2D registered on the National Diabetes Services Scheme vs a randomly sampled, population-based comparison group; linked national registries
- Participants
- 891,418 vs 1,131,369
- Exposure
- T2D vs no diabetes
- T2Dn = 891,418
- Comparisonn = 1,131,369reference
- Outcome
- Composite of:
- All-cause dementia death
- First dementia medication prescription (cholinesterase inhibitors or memantine)
Methodological detailslinked national registries
- Linked national registries
Main finding
As reported in the abstract
Composite of:
- All-cause dementia death
- Dementia medication prescription
Rate of dementia death/medication prescription, people with ten years of diabetes duration, times higher (95% CI 1.2, 1.3)
∼1.3
Rate of dementia death/medication prescription, people with five years of diabetes duration, times higher
1.1
95% CI 1.1, 1.2
Observational data: associations, not effects.
Further findings
Vascular dementia death
- Diabetes associated with higher incidence of vascular dementia death
Alzheimer's disease (AD) death
- Increased risk only beyond ∼10 years of diabetes duration
Dementia medication prescription
- Lower incidence among people with diabetes
Original publication
Impact of type 2 diabetes and its duration on incidence rates of dementia death and medication prescription in the Australian population during 2003–2016. Diabetes Res Clin Pract. Published 30 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →