Effect of early healthcare visits on cardiovascular disease risk in people with newly screened diabetes: emulating a target trial using a large insurance database
Authors' conclusion
Early healthcare visits within one year of diabetes identification were associated with a lower 10-year CVD risk. Health systems should facilitate early follow-up after screening to translate early detection into cardiovascular benefit.
Study context
- Population
- Adults aged 40–74 years with newly identified diabetes (HbA1c ≥ 6.5 % or fasting glucose ≥126 mg/dL) at annual health checkups, 2005–2021, no prior cardiovascular disease (CVD); JMDC Claims Database, Japan; mean age 53 years, 77 % men
- Participants
- 148,288 adults421,466 person-years
- Exposure
- Early healthcare visits within one year of diabetes identification vs no visits
- Outcome
- Composite CVD outcome
- Follow-up
- 10 years
Methodological detailsnationwide, weighted pooled logistic regression
- Nationwide
- Weighted pooled logistic regression
Main finding
As reported in the abstract
10-year composite CVD risk
Each group vs no-visitRisk difference, percentage points (95 % CI)
Early-visit
−3.4(−6.2 to −1.4)
Each group vs no-visitRisk ratio (95 % CI)
Early-visit
0.73(0.59–0.87)
- CVD events overall
- 1,741
Observational data: associations, not effects.
Further findings
Subgroup analyses
- Consistent results across various characteristics
Original publication
Effect of early healthcare visits on cardiovascular disease risk in people with newly screened diabetes: emulating a target trial using a large insurance database. Diabetes Res Clin Pract. Published 23 November 2025. doi:10.
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