Impact of lifestyle changes on prediabetes remission: Results from the Pakistan diabetes prevention trial
Primary result · Reversal to normoglycemiaResult — go to the resultAdjusted odds ratio 2.46 95 % CI 1.84–3.29Authors' conclusion
Culturally tailored lifestyle interventions can significantly induce prediabetes remission, highlighting scalable, low-cost prevention strategies for Pakistan and other LMICs.
Study context
- Population
- High-risk adults aged 30–64 years (Indian Diabetes Risk Score) in two sub-towns of Karachi; mean age 44 years, 74 % women, 43 % with prediabetes at baseline3,945 screened
- Participants
- 2,165 adults
- Comparison
- Culturally adapted lifestyle intervention vs standard care
- Primary endpoint
- Prediabetes remission (reversal to normoglycemia)
- Follow-up
- One and two years
Primary result
Reversal to normoglycemia · two years
Adjusted odds ratio
2.46
95 % CI 1.84–3.29
P < 0.0001
By group
Interventionvs Standard care
AOR 2.46 (95 % CI 1.84–3.29); P < 0.0001
As reported in the abstract
Further findings
Prediabetes remission by BMI category
- Lower remission among overweight participants, aOR
- 0.65
- Lower remission among pre-obese participants, aOR
- 0.59
- Lower remission among obese participants, aOR
- 0.74
Remission in areas with parks
- Lower remission in areas with parks, aOR
- 0.77, p = 0.0001
Remission in metabolic syndrome participants in the intervention
- Higher remission rates, aOR
- 4.13
Remission in impaired fasting glucose
- Markedly greater remission odds, aOR
- 8.21
Original publication
Impact of lifestyle changes on prediabetes remission: Results from the Pakistan diabetes prevention trial. Diabetes Res Clin Pract. Published 23 November 2025. doi:10.
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