Diabetes modifies the association between the triglyceride-glucose index and subclinical myocardial injury: A prospective cohort study
Authors' conclusion
A U-shaped association between the TyG index and the incidence of subclinical myocardial injury was observed for the first time. Diabetes may be a critical modifier of the association between the TyG index and subclinical myocardial injury. Considering the risk stratification value of the TyG index based on diabetes status may hold significant clinical value.
Study context
- Population
- Individuals without known CVD from the Atherosclerosis Risk in Communities (ARIC) cohort; cross-sectional mean age 56.78 years, 42.44% male8,801 in prospective cohort
- Participants
- 11,478 individuals
- Exposure
- Triglyceride-glucose (TyG) index vs subclinical myocardial injury, by diabetes status
- Outcome
- Subclinical myocardial injury (hs-cTnT ≥14 ng/L)
Methodological detailscross-sectional and prospective cohort designs, ARIC cohort
- Cross-sectional and prospective cohort designs
- ARIC cohort
Main finding
As reported in the abstract
Linear regression, overall
r = 0.13
p < 0.001
Logistic regression, overall
aOR = 1.33
p < 0.001
Diabetic participants
aOR = 1.64
p = 0.020
Non-diabetic participants (not significant)
aOR = 0.89
p = 0.374
Observational data: associations, not effects.
Further findings
Incidence of hs-cTnT elevation (prospective) · six-year follow-up
- L-shaped association, participants without diabetes
- aOR = 0.72, p = 0.006
- J-shaped association, participants with diabetes
- aOR = 2.09, p < 0.001
- U-shaped association between TyG index and incident hs-cTnT elevation, overall
Original publication
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