Joint triglyceride–glucose index and single-point insulin sensitivity estimator phenotypes and diabetes outcomes across three populations
Main finding · Diabetes-related outcomes, CHARLS (median-based)Result — go to the resultOdds ratio 2.65 95% CI 2.05–3.45Authors' conclusion
High TyG/low SPISE was associated with diabetes-related outcomes across the three populations. SPISE provided incremental information beyond TyG, with gains varying by comparator and study design.
Study context
- Population
- Participants without baseline diabetes from China Health and Retirement Longitudinal Study (CHARLS) and English Longitudinal Study of Ageing (ELSA), with National Health and Nutrition Examination Survey (NHANES) as secondary cross-sectional evidencethree populations · CHARLS 4,933 · ELSA (wave 6) 2,703 · NHANES 10,080
- Exposure
- Joint TyG and single-point insulin sensitivity estimator (SPISE) phenotypes and diabetes-related outcomes
- Outcome
- Diabetes-related outcomes, CHARLS (median-based)
Methodological detailsadjusted logistic, Cox, and survey-weighted logistic models, sample medians and literature-based fixed thresholds defined phenotypes, ELSA wave 4 sensitivity
- Adjusted logistic, Cox, and survey-weighted logistic models
- Sample medians and literature-based fixed thresholds defined phenotypes
- ELSA wave 4 sensitivity
Main finding
As reported in the abstract
Odds ratio
2.65
95% CI 2.05–3.45
High TyG/low SPISE
odds ratio 2.65 (95% CI 2.05–3.45)
Observational data: associations, not effects.
Further findings
Diabetes-related outcomes, ELSA (median-based)
| Hazard ratio (CI) | ||
|---|---|---|
| High TyG/low SPISEComparator not stated | 3.57 (2.04–6.25) | |
| High TyG/low SPISEComparator not stated | 6.41 (3.98–10.33) | |
| 0.050.21520Hazard ratio (log scale) |
Prevalent diabetes, NHANES (median-based)
| Odds ratio (CI) | ||
|---|---|---|
| High TyG/low SPISEComparator not stated | 6.61 (5.40–8.08) | |
| 0.10.31310Odds ratio (log scale) |
Dysglycemia, NHANES (median-based)
| Odds ratio (CI) | ||
|---|---|---|
| High TyG/low SPISEComparator not stated | 4.05 (3.47–4.72) | |
| 0.20.5125Odds ratio (log scale) |
Fixed-threshold associations
- Fixed-threshold associations retained the adverse direction
Incremental fit
- Adding TyG and interaction to SPISE did not improve CHARLS fit
- P = 0.251
- SPISE improved fit beyond TyG
Original publication
Joint triglyceride–glucose index and single-point insulin sensitivity estimator phenotypes and diabetes outcomes across three populations. Diabetes Res Clin Pract. Published 11 November 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →