Association between triglyceride glucose index and biological aging in U.S. adults: National Health and Nutrition Examination Survey
Authors' conclusion
There is a significant positive association between the TyG index and biological aging. Higher TyG levels are linked to increased biological age and a greater risk of accelerated aging.
Study context
- Population
- US adults aged ≥20 years, National Health and Nutrition Examination Survey (NHANES); mean age 46.91 years (SD, 16.64), 50.25% female
- Participants
- 12,074 adults
- Exposure
- Per 1-unit increase in Triglyceride-glucose (TyG) index
- Outcome
- Biological age (KDM biological age, phenotypic age) and accelerated aging
Methodological detailsNHANES 2001-2010 and 2015-2018 cycles
- NHANES 2001-2010 and 2015-2018 cycles
Main finding
As reported in the abstract
Biological aging per 1-unit increase in TyG index
Klemera-Doubal method (KDM) biological age rise
1.64-year
Higher risk of accelerated aging (KDM)
117%
Phenotypic age increase
0.40-year
Higher risk of accelerated aging (phenotypic age)
15%
Observational data: associations, not effects.
Further findings
Nonlinear relationship between TyG index and biological aging
- KDM biological age, P for non-linearity
- < 0.001
- Phenotypic age, P for non-linearity
- 0.005
- Turning point
- 8.66
Subgroups
- TyG index consistently positively correlated with biological aging across all subgroups, even with significant interactions
Original publication
Association between triglyceride glucose index and biological aging in U.S. adults: National Health and Nutrition Examination Survey. Cardiovasc Diabetol. Published 28 February 2025. doi:10.
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