Association between the triglyceride-glucose index and impaired cardiovascular fitness in non-diabetic young population
Authors' conclusion
In non-diabetic young population, individuals with higher TyG index values are at an increased likelihood of encountering impaired CVF. Furthermore, sex may exert an impact on CVF, as males tend to be more susceptible to impaired CVF under comparable TyG index conditions.
Study context
- Population
- Non-diabetic young population, National Health and Nutrition Examination Survey (NHANES) 1999–2004, who completed a cardiovascular fitness (CVF) examination; median age 28 (19–37) years
- Participants
- 3,364 participants
- Exposure
- Triglyceride-glucose (TyG) index and impaired cardiovascular fitness
- Outcome
- Impaired CVF: low and moderate CVF levels by estimated Vo2max, sex- and age-specific criteria
Main finding
As reported in the abstract
Impaired CVF per 1-unit increase in TyG index
OR for impaired CVF per 1-unit increase in TyG index (multivariable logistic regression)
1.46
95% Cl 1.13–1.90
Observational data: associations, not effects.
Further findings
Interaction between sex and TyG index for impaired CVF, age < 20 years
- Significant sex × TyG index interaction
- P = 0.027
TyG index
- TyG index (median ± SD)
- 8.36 ± 0.52
Original publication
Association between the triglyceride-glucose index and impaired cardiovascular fitness in non-diabetic young population. Cardiovasc Diabetol. Published 20 January 2024. doi:10.
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