Circulating palmitoyl sphingomyelin levels predict the 10-year increased risk of cardiovascular disease death in Chinese adults: findings from the Da Qing Diabetes Study
Main finding · CVD death incidence by PSM tertileResult — go to the resultHazard ratio 2.73 95% CI 1.20–6.22Authors' conclusion
Elevated PSM levels are significantly associated with a higher 10-year risk of CVD death, but not non-CVD death, in Chinese adults with diabetes. These findings suggest that PSM is a potentially useful long-term predictor of CVD death in individuals with diabetes.
Study context
- Population
- Chinese adults with or without diabetes from the original Da Qing Diabetes Study; baseline blood samples 2009286 with and 219 without DM · Chinese adults with 286 · or without 219
- Exposure
- Highest vs lowest palmitoyl sphingomyelin (PSM) tertile
- Outcome
- CVD death
- Follow-up
- 2009 to 2020
Methodological detailsfollow-up of the Da Qing Diabetes Study
- Follow-up of the Da Qing Diabetes Study
Main finding
CVD death incidence by PSM tertile
Hazard ratio
2.73
95% CI 1.20–6.22
Highest PSM tertilevs Lowest PSM tertile
HR 2.73 (95% CI 1.20–6.22)
As reported in the abstract
- Linear association of baseline PSM (log-2) with cardiovascular disease (CVD) death, all participants, adjusted
- P < 0.001
- CVD death incidence, highest tertile vs comparator, with DM (per 1000 person-years)
- 41.5 vs. 14.7
- CVD death incidence, highest tertile vs comparator, without DM (per 1000 person-years)
- 22.2 vs. 2.9
Observational data: associations, not effects.
Further findings
All-cause and non-CVD death · 2009 to 2020
- Linear association of PSM with all-cause death
- P < 0.001
- No association with non-CVD death
- P > 0.05
- Deaths during follow-up
- 178, including 87 due to CVD
Original publication
Circulating palmitoyl sphingomyelin levels predict the 10-year increased risk of cardiovascular disease death in Chinese adults: findings from the Da Qing Diabetes Study. Cardiovasc Diabetol. Published 20 January 2024. doi:10.
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