Diabetes mellitus is associated to high-risk late gadolinium enhancement and worse outcomes in patients with nonischemic dilated cardiomyopathy
Main finding · Composite of HF hospitalisation and all-cause mortalityResult — go to the resultOdds ratio 2.01Authors' conclusion
DM is related to a higher presence of LGE in DCM patients and is an independent predictor of outcomes. Patients with DM and LGE had a threefold risk of events. A multimodality imaging approach allows better risk stratification of these patients and may influence therapeutic options.
Study context
- Population
- Patients with nonischemic dilated cardiomyopathy (DCM) evaluated in a tertiary care center, 2018–2021
- Participants
- 192 patients
- Exposure
- Diabetes mellitus (DM) vs no DM
- DMn = 51
- Outcome
- Composite of:
- HF hospitalizations
- All-cause mortality
Methodological detailssingle-centre, tertiary care center
- Single-centre
- Tertiary care center
Main finding
As reported in the abstract
Composite of:
- HF hospitalisation
- All-cause mortality
Odds ratio
2.01
P = 0.049
Observational data: associations, not effects.
Further findings
LGE
P = 0.025
High-risk LGE pattern (epicardial, transmural, or septal plus free-wall)
P = 0.047
| Outcome | DM | No DM | OR | P value |
|---|---|---|---|---|
| LGEMultivariable analysis; LGE presence | 2.15 | P = 0.048 | ||
| E/e values | 15 | 11.9 | P = 0.025 |
Systolic function parameters
- No significant differences between patients with and without DM
Events in patients with both DM and late gadolinium enhancement (LGE)
- Patients with both DM and LGE had the highest risk of events (HR)
- 3.1; p = 0.003
Original publication
Diabetes mellitus is associated to high-risk late gadolinium enhancement and worse outcomes in patients with nonischemic dilated cardiomyopathy. Cardiovasc Diabetol. Published 20 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →