Association of changes in the type 2 diabetes and MASLD /related SLD status with risk of developing cardiovascular disease
Authors' conclusion
The association of MASLD/r-SLD remission with CVD risk differs greatly in the presence and absence of DM. In patients with DM-MASLD/r-SLD, MASLD/r-SLD remission can significantly reduce CVD risk similarly as remission of DM.
Study context
- Population
- Participants aged 18–72 years with ≥3 years of follow-up and MASLD/related SLD (r-SLD) at baseline, health examination data from a nationwide claims database in Japan
- Participants
- 9,345 vs 71,932
- Exposure
- Remission of diabetes mellitus (DM) and/or MASLD/r-SLD at 2 years vs no remission
- DM-associated MASLD/r-SLDn = 9,345
- Non-DM MASLD/r-SLDn = 71,932
- Outcome
- New-onset CVD
- Follow-up
- Median 4.9 years (starting from 2-Years)
Methodological detailsnationwide claims database, multivariate Cox proportional hazards models
- Nationwide claims database
- Multivariate Cox proportional hazards models
Main finding
As reported in the abstract
New-onset CVD in DM-associated MASLD/r-SLD, by remission status at 2-Years
HR for CVD (95% CI)
Remission of DM
0.50(0.31–0.80)
Remission of MASLD/r-SLD
0.65(0.47–0.91)
Remission of both DM and MASLD/r-SLD
0.34(0.15–0.77)
- Cardiovascular disease (CVD) cases observed
- 1368
Observational data: associations, not effects.
Original publication
Association of changes in the type 2 diabetes and MASLD /related SLD status with risk of developing cardiovascular disease. Diabetes Obes Metab. Published 15 January 2025. doi:10.
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